Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes
نویسندگان
چکیده
منابع مشابه
ALL promoter - usage is not linked to glucocorticoid resistance in childhood Glucocorticoid - induced glucocorticoid receptor expression
(4217 articles) Neoplasia (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Informati...
متن کاملRole of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
The mechanisms by which glucocorticoid receptor (GR) mediates glucocorticoid (GC)-induced apoptosis are unknown. We studied the role of mitochondrial GR in this process. Dexamethasone induces GR translocation to the mitochondria in GC-sensitive, but not in GC-resistant, T cell lines. In contrast, nuclear GR translocation occurs in all cell types. Thymic epithelial cells, which cause apoptosis o...
متن کاملExpression of glucocorticoid receptor gene isoforms in corticotropin-secreting tumors.
The molecular basis of Cushing's disease is not known. One of the most characteristic features of such tumors is their resistance to corticosteroid feedback at the pituitary level. We have hypothesized that abnormalities of the glucocorticoid receptor (GR) gene might play a role in the development of Cushing's disease via an increase in the relative production of the nonligand-binding splice va...
متن کاملThe Mechanism of CAMP - induced Glucocorticoid Receptor Expression CORRELATION TO CELLULAR GLUCOCORTICOID
The mechanism of regulation of glucocorticoid receptor (GR) expression by cAMP was investigated in rat hepatoma cells (HTC). Incubation of HTC cells with the CAMP-inducing agent, forskolin, caused a significant increase in the levels of both [SH]dexamethasone binding capacity and GR mRNA by about 2to 2.4fold within 4 h. Incubation of HTC cells with the cAMP analogue, 8-bromo-cAMP, also incre...
متن کاملGlucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells.
Although glucocorticoids play an important role in the treatment of multiple myeloma, some patients do not respond or develop resistance. The glucocorticoid receptor (GR), a single gene, mediates the effects of glucocorticoids. Using a model system of a multiple myeloma cell line sensitive to glucocorticoids and its early and late resistant variants, we have analyzed mutations in the GR gene, d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Steroid Biochemistry and Molecular Biology
سال: 2008
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2008.01.002